High-resolution photoacoustic tomography of resting-state functional connectivity in the mouse brain

The increasing use of mouse models for human brain disease studies presents an emerging need for a new functional imaging modality. Using optical excitation and acoustic detection, we developed a functional connectivity photoacoustic tomography system, which allows noninvasive imaging of resting-sta...

Full description

Saved in:
Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 2014-01, Vol.111 (1), p.21-26
Main Authors: Nasiriavanaki, Mohammadreza, Xia, Jun, Wan, Hanlin, Bauer, Adam Quentin, Culver, Joseph P., Wang, Lihong V.
Format: Article
Language:English
Subjects:
Algorithms
Animals
Biological Sciences
Brain
Brain - pathology
Brain hypoxia
Brain Mapping - methods
Connectivity
Correlation analysis
Disease Models, Animal
Electrodes
Equipment Design
Functional neuroimaging
Hemodynamics
Hemoglobins - metabolism
Hyperoxia
Hypoxia
Image Processing, Computer-Assisted - methods
Imaging
Lasers
Magnetic resonance imaging
Male
Mice
Neural Pathways
Neurosciences
Normal Distribution
Photoacoustic Techniques - methods
Physical Sciences
Pixels
Rodents
Tomography
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The increasing use of mouse models for human brain disease studies presents an emerging need for a new functional imaging modality. Using optical excitation and acoustic detection, we developed a functional connectivity photoacoustic tomography system, which allows noninvasive imaging of resting-state functional connectivity in the mouse brain, with a large field of view and a high spatial resolution. Bilateral correlations were observed in eight functional regions, including the olfactory bulb, limbic, parietal, somatosensory, retrosplenial, visual, motor, and temporal regions, as well as in several subregions. The borders and locations of these regions agreed well with the Paxinos mouse brain atlas. By subjecting the mouse to alternating hyperoxic and hypoxic conditions, strong and weak functional connectivities were observed, respectively. In addition to connectivity images, vascular images were simultaneously acquired. These studies show that functional connectivity photoacoustic tomography is a promising, noninvasive technique for functional imaging of the mouse brain.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.1311868111