Impact of puberty on the evolution of cerebral perfusion during adolescence

Puberty is the defining biological process of adolescent development, yet its effects on fundamental properties of brain physiology such as cerebral blood flow (CBF) have never been investigated. Capitalizing on a sample of 922 youths ages 8–22 y imaged using arterial spin labeled MRI as part of the...

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Published in:Proceedings of the National Academy of Sciences - PNAS 2014-06, Vol.111 (23), p.8643-8648
Main Authors: Satterthwaite, Theodore D., Shinohara, Russell T., Wolf, Daniel H., Hopson, Ryan D., Elliott, Mark A., Vandekar, Simon N., Ruparel, Kosha, Calkins, Monica E., Roalf, David R., Gennatas, Efstathios D., Jackson, Chad, Erus, Guray, Prabhakaran, Karthik, Davatzikos, Christos, Detre, John A., Hakonarson, Hakon, Gur, Ruben C., Gur, Raquel E.
Format: Article
Language:English
Subjects:
Adolescence
Adolescent
Biological Sciences
Blood flow
Brain - blood supply
Brain research
Cerebral Arteries - physiology
Cerebrovascular Circulation - physiology
Child
Child development
Cohort Studies
Estrogens
Female
Gray matter
Humans
Imaging
Magnetic Resonance Imaging - methods
Male
Neurosciences
Perfusion
Prefrontal cortex
Puberty
Puberty - physiology
Sex Factors
Sex linked differences
Spin Labels
Time Factors
Trajectories
Young Adult
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Summary:Puberty is the defining biological process of adolescent development, yet its effects on fundamental properties of brain physiology such as cerebral blood flow (CBF) have never been investigated. Capitalizing on a sample of 922 youths ages 8–22 y imaged using arterial spin labeled MRI as part of the Philadelphia Neurodevelopmental Cohort, we studied normative developmental differences in cerebral perfusion in males and females, as well as specific associations between puberty and CBF. Males and females had conspicuously divergent nonlinear trajectories in CBF evolution with development as modeled by penalized splines. Seventeen brain regions, including hubs of the executive and default mode networks, showed a robust nonlinear age-by-sex interaction that surpassed Bonferroni correction. Notably, within these regions the decline in CBF was similar between males and females in early puberty and only diverged in midpuberty, with CBF actually increasing in females. Taken together, these results delineate sex-specific growth curves for CBF during youth and for the first time to our knowledge link such differential patterns of development to the effects of puberty.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.1400178111