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Soluble HLA-G Protein Secreted by Allo-Specific CD4+T Cells Suppresses the Allo-Proliferative Response: A CD4+T Cell Regulatory Mechanism

We recently reported that the nonclassical HLA class I molecule HLA-G was expressed in the endomyocardial biopsies and sera of 16% of heart transplant patients studied. The aim of the present report is to identify cells that may be responsible for HLA-G protein expression during the allogeneic react...

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Published in:Proceedings of the National Academy of Sciences - PNAS 2001-10, Vol.98 (21), p.12150-12155
Main Authors: Lila, Nermine, Rouas-Freiss, Nathalie, Dausset, Jean, Carpentier, Alain, Carosella, Edgardo D.
Format: Article
Language:English
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Summary:We recently reported that the nonclassical HLA class I molecule HLA-G was expressed in the endomyocardial biopsies and sera of 16% of heart transplant patients studied. The aim of the present report is to identify cells that may be responsible for HLA-G protein expression during the allogeneic reaction. Carrying out mixed lymphocyte cultures in which the responder cell population was depleted either in CD4+or CD8+T cells, we found that soluble HLA-G5 protein but not the membrane-bound HLA-G isoform was secreted by allo-specific CD4+T cells from the responder population, which suppressed the allogeneic proliferative T cell response. This inhibition may be reversed by adding the anti-HLA-G 87G antibody to a mixed lymphocyte culture. That may indicate a previously uncharacterized regulatory mechanism of CD4+T cell proliferative response.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.201407398