Functional Communication between Endogenous BRCA1 and Its Partner, BARD1, during Xenopus laevis Development

The breast and ovarian susceptibility protein 1 (BRCA1) heterodimerizes with its structural relative, the BRCA1-associated RING domain protein (BARD1), which may have tumor suppressing function in its own right. Both proteins have evolved from a common evolutionary ancestor, and both exist in Xenopu...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 2001-10, Vol.98 (21), p.12078-12083
Main Authors: Joukov, Vladimir, Chen, Junjie, Fox, Edward A., Jeremy B. A. Green, Livingston, David M.
Format: Article
Language:English
Subjects:
Animals
BARD1 protein
Base Sequence
Biological Sciences
BRCA1 protein
BRCA1 Protein - genetics
BRCA1 Protein - physiology
Breast cancer
Carrier Proteins - genetics
Carrier Proteins - physiology
Cellular biology
Complementary DNA
Conserved Sequence
Dimerization
DNA
DNA, Complementary
Embryos
Freshwater
Frogs
Gene Expression
Humans
Mathematical functions
Messenger RNA
Molecular Sequence Data
Oligonucleotides, Antisense
Oocytes - metabolism
Ovarian cancer
Phenotypes
Proteins
RNA
T lymphocytes
Tumor Suppressor Proteins
Tumors
Ubiquitin-Protein Ligases
Xenopus
Xenopus laevis
Xenopus laevis - embryology
Zinc Fingers - genetics
Zinc Fingers - physiology
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Summary:The breast and ovarian susceptibility protein 1 (BRCA1) heterodimerizes with its structural relative, the BRCA1-associated RING domain protein (BARD1), which may have tumor suppressing function in its own right. Both proteins have evolved from a common evolutionary ancestor, and both exist in Xenopus laevis where, similar to their mammalian homologs, they form functional heterodimers. Depleting frog embryos of either BARD1 or BRCA1 led to similar and widely defective developmental phenotypes as well as depletion of the other polypeptide due to its decreased stability. Thus, each protein, in part, controls the abundance, stability, and function of the other, and these effects are heterodimerization-dependent. The interdependent nature of BRCA1 and BARD1 function supports the view that BARD1/BRCA1 heterodimers play a major role in breast and ovarian cancer suppression.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.211427098