Ultrastructure of the Human Complement Component, Clq

The human complement component, Clq, is a fragile molecule of delicate structure consisting of three distinct parts, a central subunit, connecting strands, and terminal subunits. Each terminal subunit is further subdivided into a large and a small subunit, and the central subunit appears to be divid...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 1972-01, Vol.69 (1), p.65-68
Main Authors: Shelton, Emma, Yonemasu, Kunio, Stroud, Robert M.
Format: Article
Language:English
Subjects:
Acetates
Biochemistry
Biological Sciences: Immunology
Centrifugation
Complement System Proteins - analysis
Complement System Proteins - isolation & purification
Electron microscopy
Enzymes
Escherichia coli - enzymology
Glutamate-Ammonia Ligase
Humans
Immune Sera
Immunodiffusion
Immunoglobulins
Immunology
Magnification
Microscopy, Electron
Molecular structure
Molecular weight
Molecules
Protein Conformation
Staining and Labeling
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Description
Summary:The human complement component, Clq, is a fragile molecule of delicate structure consisting of three distinct parts, a central subunit, connecting strands, and terminal subunits. Each terminal subunit is further subdivided into a large and a small subunit, and the central subunit appears to be divided into two equal parts. In the intact molecule, six connecting strands link six terminal subunits by their larger subdivision to the central subunit. The overall diameter of the molecule when viewed from the ``top'' is about 35 nm (350 angstrom).
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.69.1.65