Urotensin II: A somatostatin-Like Peptide in the Caudal Neurosecretory System of Fishes

Urotensin II, a peptide hormone from the caudal neurosecretory system of the teleost, Gillichthys mirabilis, was isolated by using classical chromatographic techniques and high-performance liquid chromatography (HPLC). Direct microtechniques for sequence determination were used to establish its stru...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 1980-08, Vol.77 (8), p.5021-5024
Main Authors: Pearson, David, Shively, John E., Clark, Brian R., Geschwind, Irving I., Barkley, Marylynn, Nishioka, Richard S., Bern, Howard A.
Format: Article
Language:English
Subjects:
Acetates
Amino Acid Sequence
Amino acids
Animals
Biochemistry
Chemical composition
Chromatography
Chromatography, High Pressure Liquid
Elution
Fishes - physiology
Hormones
Neurosecretory systems
Neurosecretory Systems - analysis
Peptides - isolation & purification
Quaternary ammonium compounds
Sequence analysis
Somatostatin - analysis
Structure-Activity Relationship
Urotensins - isolation & purification
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Summary:Urotensin II, a peptide hormone from the caudal neurosecretory system of the teleost, Gillichthys mirabilis, was isolated by using classical chromatographic techniques and high-performance liquid chromatography (HPLC). Direct microtechniques for sequence determination were used to establish its structure. Urotensin II from Gillichthys is a 1363-dalton dodecapeptide with the amino acid sequence Ala-Gly-Thr-Ala-Asp-Cys-Phe-Trp-Lys-Tyr-Cys-Val. This sequence is homologous with somatostatin in positions 1 and 2 and 7-9. The sequence has been verified by the production of a bioactive synthetic urotensin II. The possible chemical and physiological significance of its homology to somatostatin is discussed.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.77.8.5021