Preparation of Tritium- or Deuterium-Labeled Vitamin D Analogs by a Convenient General Method

The three-step conversion of vitamin D analogs to 6-oxo-3,5-cyclovitamin D derivatives followed by reduction with a tritide or deuteride reagent and subsequent cycloreversion gives 6-tritio(deutero)vitamin D derivatives and corresponding 5,6-trans-analogs. The method is general and affords the 6-lab...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 1981-10, Vol.78 (10), p.6173-6175
Main Authors: Paaren, Herbert E., Fivizzani, Mary A., Schnoes, Heinrich K., DeLuca, Hector F.
Format: Article
Language:English
Subjects:
Acetates
Biochemistry
Biological Sciences: Biochemistry
Cholecalciferol
Deuterium
Dioxides
Ergocalciferols
Ethers
Isotope Labeling - methods
Manganese
Metabolism
Product labeling
Reagents
Solvolysis
Tritium
Vitamin D
Vitamin D - analogs & derivatives
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Description
Summary:The three-step conversion of vitamin D analogs to 6-oxo-3,5-cyclovitamin D derivatives followed by reduction with a tritide or deuteride reagent and subsequent cycloreversion gives 6-tritio(deutero)vitamin D derivatives and corresponding 5,6-trans-analogs. The method is general and affords the 6-labeled-vitamin D analogs in ≈ 20% overall yield.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.78.10.6173