Salmonella typhimurium phoP virulence gene is a transcriptional regulator

Salmonella typhimurium is a faculative intracellular pathogen capable of surviving within host phagocytic cells. Salmonella strains carrying phoP mutations are avirulent, unable to survive in macrophages, and extremely sensitive to peptides having antimicrobial activity such as the host-derived defe...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 1989-09, Vol.86 (18), p.7077-7081
Main Authors: Groisman, E.A. (University of California at San Diego, La Jolla, CA), Chiao, E, Lipps, C.J, Heffron, F
Format: Article
Language:English
Subjects:
ACIDE AMINE
Amino Acid Sequence
AMINO ACIDS
AMINOACIDOS
Bacterial Proteins - genetics
Bacteriology
Base Sequence
Biological and medical sciences
DNA
DNA, Bacterial - genetics
Escherichia coli - genetics
FAGOCITOS
Fundamental and applied biological sciences. Psychology
GENE
GENES
Genes, Bacterial
Genes, Regulator
Genetic loci
Genotype
Microbiology
Molecular Sequence Data
MUTACION
MUTATION
NUCLEOTIDE
NUCLEOTIDES
NUCLEOTIDOS
Operator regions
Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains
PHAGOCYTE
PHAGOCYTES
Phenotypes
Phosphatases
Phosphates
Plasmids
Restriction Mapping
SALMONELLA
Salmonella typhimurium - genetics
Salmonella typhimurium - pathogenicity
Sequence Homology, Nucleic Acid
Transcription, Genetic
VIRULENCE
VIRULENCIA
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Description
Summary:Salmonella typhimurium is a faculative intracellular pathogen capable of surviving within host phagocytic cells. Salmonella strains carrying phoP mutations are avirulent, unable to survive in macrophages, and extremely sensitive to peptides having antimicrobial activity such as the host-derived defensins. We present here the DNA sequence of the phoP gene and show that the deduced amino acid sequence of phoP has extensive homology with the Escherichia coli transcriptional regulators PhoB and OmpR, which control the expression of loci in response to different environmental stimuli. The psiD locus, which is regulated by phosphate availability, was found to be under the control of the phoP gene product. Sequences homologous to phoP were found in several Gram-negative species and in the yeast Saccharomyces cerevisiae.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.86.18.7077