v-maf, a Viral Oncogene that Encodes a "Leucine Zipper" Motif

We have molecularly cloned the provirus of the avian musculoaponeurotic fibrosarcoma virus AS42. Nucleotide sequence analysis of a biologically active clone of AS42 showed that this virus encodes a viral oncogene, maf. The deduced amino acid sequence of the v-maf gene product contains a ``leucine zi...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 1989-10, Vol.86 (20), p.7711-7715
Main Authors: Nishizawa, Makoto, Kataoka, Kohsuke, Goto, Naoaki, Fujiwara, Kosaku T., Kawai, Sadaaki
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Amino acids
Animals
avian musculoaponeurotic fibrosarcoma virus
Avian Sarcoma Viruses - genetics
Base Sequence
Blood cells
Cells, Cultured
Chickens
Cloning, Molecular
DNA
Fibroblasts
Genes
Genes, Viral
Molecular Sequence Data
Nucleotide sequences
Oncogene Proteins, Viral - genetics
Oncogenes
Proteins
Proviruses
Restriction Mapping
Sequence Homology, Nucleic Acid
Transfection
Viruses
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Summary:We have molecularly cloned the provirus of the avian musculoaponeurotic fibrosarcoma virus AS42. Nucleotide sequence analysis of a biologically active clone of AS42 showed that this virus encodes a viral oncogene, maf. The deduced amino acid sequence of the v-maf gene product contains a ``leucine zipper'' motif similar to that found in a number of DNA binding proteins, including the gene products of the fos, jun, and myc oncogenes. However, unlike these oncogenes, the cellular maf gene was not transcriptionally activated by growth stimulation of cultured cells.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.86.20.7711