Midline Signaling in the Primordium of the Zebrafish Anterior Central Nervous System

In all vertebrates the brain develops from the enlarged anterior part of the neural plate. However, in the zebrafish mutant cyclops, the girth of the central nervous system (CNS) is nearly uniform along its length. Changes in expression patterns of homeobox genes and neuronal markers reveal a massiv...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 1994-03, Vol.91 (6), p.2061-2065
Main Authors: Hatta, Kohei, Puschel, Andreas W., Kimmel, Charles B.
Format: Article
Language:English
Subjects:
Animals
Biology
Cell transplantation
Central nervous system
Central Nervous System - embryology
Central Nervous System - physiology
Cyclopes
Danio rerio
Diencephalon
Embryo, Nonmammalian
Embryos
Fish
Forebrain
Freshwater
Genes, Homeobox
Midbrain
Mosaic
Nervous system
Neurons
Phenotype
Phenotypes
Prosencephalon - embryology
Prosencephalon - physiology
Prosencephalon - transplantation
Signal Transduction
Zebrafish
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Summary:In all vertebrates the brain develops from the enlarged anterior part of the neural plate. However, in the zebrafish mutant cyclops, the girth of the central nervous system (CNS) is nearly uniform along its length. Changes in expression patterns of homeobox genes and neuronal markers reveal a massive deletion of the ventral forebrain, particularly the diencephalon, as well as its precursor region in the neural plate. The deletion is due to a nonautonomous action of the mutation: very few wild-type cells transplanted to the midline of a mutant embryo can rescue the forebrain phenotype, including cyclopia. Establishment of forebrain ventral positional coordinates may thus require inductive signaling by forebrain midline cells whose specification depends upon the cyclops gene product.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.91.6.2061