Expression Pattern of HIV-1 Coreceptors on T Cells: Implications for Viral Transmission and Lymphocyte Homing

A model is proposed that may explain why only M-tropic virus can transmit HIV infection. Understanding the physiological role and regulation of HIV coreceptors on different subsets of T cells will guide future strategies for deploying therapeutics that block entry of HIV into target cells.

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 1997-03, Vol.94 (5), p.1615-1618
Main Authors: Unutmaz, Derya, Littman, Dan R.
Format: Article
Language:English
Subjects:
B lymphocytes
Cellular biology
Chemokine CXCL12
Chemokines
Chemokines - metabolism
Chemokines, CXC
Commentary
Gene Expression Regulation, Viral - genetics
HIV
HIV 1
HIV Infections - immunology
HIV Infections - transmission
HIV Infections - virology
HIV-1 - metabolism
Human immunodeficiency virus
human immunodeficiency virus 1
Humans
Immunity (Disease)
Infections
Leukocyte Common Antigens - immunology
Lymphocytes
Lymphocytes - metabolism
Membrane Proteins - metabolism
Memory
Models, Immunological
Molecular biology
Receptors
Receptors, CCR5
Receptors, CXCR4
Receptors, Cytokine - metabolism
Receptors, HIV - genetics
Receptors, HIV - metabolism
T lymphocytes
T-Lymphocytes - classification
T-Lymphocytes - metabolism
Viruses
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Description
Summary:A model is proposed that may explain why only M-tropic virus can transmit HIV infection. Understanding the physiological role and regulation of HIV coreceptors on different subsets of T cells will guide future strategies for deploying therapeutics that block entry of HIV into target cells.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.94.5.1615