Tβ4 Is Not a Simple G-actin Sequestering Protein and Interacts with F-actin at High Concentration (∗)

Thymosin β4 is acknowledged as a major G-actin binding protein maintaining a pool of unassembled actin in motile vertebrate cells. We have examined the function of Tβ4 in actin assembly in the high range of concentrations (up to 300 μM) at which Tβ4 is found in highly motile blood cells. Tβ4 behaves...

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Bibliographic Details
Published in:The Journal of biological chemistry 1996-04, Vol.271 (16), p.9231-9239
Main Authors: Carlier, Marie-France, Didry, Dominique, Erk, Inge, Lepault, Jean, Van Troys, Marleen L., Vandekerckhove, Joël, Perelroizen, Irina, Yin, Helen, Doi, Yukio, Pantaloni, Dominique
Format: Article
Language:English
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Summary:Thymosin β4 is acknowledged as a major G-actin binding protein maintaining a pool of unassembled actin in motile vertebrate cells. We have examined the function of Tβ4 in actin assembly in the high range of concentrations (up to 300 μM) at which Tβ4 is found in highly motile blood cells. Tβ4 behaves as a simple G-actin sequestering protein only in a range of low concentrations (
ISSN:0021-9258
1083-351X
DOI:10.1074/jbc.271.16.9231