Structures of Phytophthora RXLR Effector Proteins

Phytopathogens deliver effector proteins inside host plant cells to promote infection. These proteins can also be sensed by the plant immune system, leading to restriction of pathogen growth. Effector genes can display signatures of positive selection and rapid evolution, presumably a consequence of...

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Bibliographic Details
Published in:The Journal of biological chemistry 2011-10, Vol.286 (41), p.35834-35842
Main Authors: Boutemy, Laurence S., King, Stuart R.F., Win, Joe, Hughes, Richard K., Clarke, Thomas A., Blumenschein, Tharin M.A., Kamoun, Sophien, Banfield, Mark J.
Format: Article
Language:English
Subjects:
Effector Protein
Host-Pathogen Interaction
Oomycete
Parasite
Plant
Protein Folding
Protein Structure
X-ray Crystallography
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Summary:Phytopathogens deliver effector proteins inside host plant cells to promote infection. These proteins can also be sensed by the plant immune system, leading to restriction of pathogen growth. Effector genes can display signatures of positive selection and rapid evolution, presumably a consequence of their co-evolutionary arms race with plants. The molecular mechanisms underlying how effectors evolve to gain new virulence functions and/or evade the plant immune system are poorly understood. Here, we report the crystal structures of the effector domains from two oomycete RXLR proteins, Phytophthora capsici AVR3a11 and Phytophthora infestans PexRD2. Despite sharing
ISSN:0021-9258
1083-351X
DOI:10.1074/jbc.M111.262303