Design of an Active Ultrastable Single-chain Insulin Analog

Single-chain insulin (SCI) analogs provide insight into the inter-relation of hormone structure, function, and dynamics. Although compatible with wild-type structure, short connecting segments (

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Bibliographic Details
Published in:The Journal of biological chemistry 2008-05, Vol.283 (21), p.14703-14716
Main Authors: Hua, Qing-xin, Nakagawa, Satoe H., Jia, Wenhua, Huang, Kun, Phillips, Nelson B., Hu, Shi-quan, Weiss, Michael A.
Format: Article
Language:English
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Description
Summary:Single-chain insulin (SCI) analogs provide insight into the inter-relation of hormone structure, function, and dynamics. Although compatible with wild-type structure, short connecting segments (
ISSN:0021-9258
1083-351X
DOI:10.1074/jbc.M800313200