Refining the risk assessment of metal-contaminated soils

Determining the bioavailability of toxic metals (Pb, As, and Cd) in a diverse range of soils, allows scientifically derived data to dictate site-specific remedies to reduce the risk for sensitive human populations. Based on a series of dosing trials in a juvenile swine model, site-specific estimates...

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Bibliographic Details
Published in:International journal of hygiene and environmental health 2001-07, Vol.203 (5), p.473-474
Main Authors: Casteel, Stan, Evans, Tim, Turk, Jim, Basta, Nick, Weis, Chris, Henningsen, Gerry, Hoffman, Eva
Format: Article
Language:English
Subjects:
Animals
bioavailability
Biological and medical sciences
Biological Availability
cadmium
Chemical and industrial products toxicology. Toxic occupational diseases
Female
fetus
Humans
Lead - adverse effects
Lead - pharmacokinetics
Lead, arsenic
Maternal-Fetal Exchange
Medical sciences
Metals and various inorganic compounds
Miscellaneous
Models, Animal
Pregnancy
Pregnancy, Animal
Public Health
Public health. Hygiene
Public health. Hygiene-occupational medicine
Risk Assessment
Sensitivity and Specificity
soil
Soil Pollutants - adverse effects
Soil Pollutants - pharmacokinetics
Swine
Tissue Distribution
Toxicology
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Summary:Determining the bioavailability of toxic metals (Pb, As, and Cd) in a diverse range of soils, allows scientifically derived data to dictate site-specific remedies to reduce the risk for sensitive human populations. Based on a series of dosing trials in a juvenile swine model, site-specific estimates of relative bioavailability of Pb in soil ranged from 3 % to 86 % compared to soluble lead acetate. Another experiment using a pregnant swine model revealed: 1) Pb accumulation in fetal tissues was 50 % or more of maternal and; 2) pregnant females accumulated 2-to-4 times more lead in tissues than unbred females. Relative bioavailability results for arsenic- and cadmium-contaminated soils further support the view that soil metals are not always as well absorbed as soluble forms, therefore use of default toxicity factors for assessing human health risk may overestimate the hazard.
ISSN:1438-4639
1618-131X
DOI:10.1078/1438-4639-00049