Effect of acetoacetate administration on urinary and tissue vitamin B 6 in rats

1. Experiments were undertaken to study the effect of daily intraperitoneal injection of acetoacetate for 90 days on vitamin B 6 status in male albino rats. The initial dose of acetoacetate was 50 mg per kg body-weight, which was increased by 50 mg per kg body-weight every 15 days. 2. Urinary excret...

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Bibliographic Details
Published in:British journal of nutrition 1969-08, Vol.23 (3), p.705-707
Main Authors: Nath, M. C., Shastri, N. V.
Format: Article
Language:English
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Summary:1. Experiments were undertaken to study the effect of daily intraperitoneal injection of acetoacetate for 90 days on vitamin B 6 status in male albino rats. The initial dose of acetoacetate was 50 mg per kg body-weight, which was increased by 50 mg per kg body-weight every 15 days. 2. Urinary excretion of vitamin B 6 was found to decrease after 30 days in acetoacetatetreated rats. After 75 days urinary values of vitamin B 6 were considerably lower in such rats than in the corresponding control rats. 3. When acetoacetate injections were stopped after 90 days and the rats were fed L-tryptophan (100mg per rat), they were found to excrete significantly greater amounts of urinary kynurenine, hydroxykynurenine and xanthurenic acid than the corresponding controls. 4. Blood and liver vitamin Be levels were found to be lower in rats treated with acetoacetate for 90 days than in the untreated rats.
ISSN:0007-1145
1475-2662
DOI:10.1079/BJN19690078