The association of inflammatory markers and echocardiographic parameters in Behçet's disease

Background: The main objective of the current study is to find out if any association exists between specific inflammatory markers such as homocysteine (Hcy) and pentraxin-3 (PTX-3) and cardiac involvement determined by means of echocardiographic parameters in patients with Behçet disease (BD). Meth...

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Bibliographic Details
Published in:Acta Cardiologica 2020-03, Vol.75 (2), p.130-137
Main Authors: Çalık, Ali Nazmi, Özcan, Kazım Serhan, Mesci, Banu, Çınar, Tufan, Çanga, Yiğit, Güngör, Barış, Kavala, Mukaddes, Oğuz, Aytekin, Bolca, Osman, Kozan, Ömer
Format: Article
Language:English
Subjects:
Adult
aortic stiffness
atrial conduction times
Behcet Syndrome - complications
Behçet disease
Biomarkers - blood
C-Reactive Protein - analysis
Cohort Studies
diastolic functions
Echocardiography
Female
Heart Diseases - blood
Heart Diseases - diagnostic imaging
Heart Diseases - etiology
homocysteine
Homocysteine - blood
Humans
Male
Middle Aged
Pentraxin-3
Serum Amyloid P-Component - analysis
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Summary:Background: The main objective of the current study is to find out if any association exists between specific inflammatory markers such as homocysteine (Hcy) and pentraxin-3 (PTX-3) and cardiac involvement determined by means of echocardiographic parameters in patients with Behçet disease (BD). Methods: From January 2011 to January 2012, a total of 62 Behçet's patients were enrolled in the study. Thirty-two healthy subjects constituted the control group. The diagnosis of BD was made as proposed by International Study Group of BD. Results: The mean PTX-3, Hcy, and C-reactive protein levels were significantly higher in patients with BD compared to the control group. The electromechanical delay (EMD) times were found to be prolonged in patients with BD. Also, the aortic stiffness index (SI) and elastic modulus (Ep) were significantly higher, while the aortic dispensibility was significantly lower in patients with BD. The left atrial volume, left atrial volume index, E/A ratio, E/E' septal, IRight-EMD, PA'-ML, PA'-MS, PA'-TL, SI, and Ep were correlated with PTX-3 levels. In addition, the E/A, PA'-ML, PA'-MS, SI, and Ep displayed correlation with Hcy levels in patients having BD. Conclusion: Elevated levels of PTX-3 and Hcy were found to be correlated with cardiac involvement determined by means of echocardiographic parameters in patients with BD.
ISSN:0001-5385
1784-973X
0373-7934
DOI:10.1080/00015385.2018.1560071