Young adult patients with squamous cell carcinoma of the tongue strongly express p16 without human papillomavirus infection

Background: Long-term smoking and drinking are known to contribute to the onset of tongue cancer (TC). However, the increasing incidence of TC in younger adults has been suggested to be associated with other factors. Objectives: The present study investigated the relationship between TC and human pa...

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Bibliographic Details
Published in:Acta oto-laryngologica 2019-01, Vol.139 (1), p.80-84
Main Authors: Tachibana, Tomoyasu, Orita, Yorihisa, Gion, Yuka, Miki, Kentaro, Ikegami, Kana, Marunaka, Hidenori, Makino, Takuma, Akagi, Yusuke, Akisada, Naoki, Tsumura, Munechika, Ito, Toshihiro, Yoshino, Tadashi, Nishizaki, Kazunori, Sato, Yasuharu
Format: Article
Language:English
Subjects:
Human papillomavirus
p16 protein
tongue cancer
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Summary:Background: Long-term smoking and drinking are known to contribute to the onset of tongue cancer (TC). However, the increasing incidence of TC in younger adults has been suggested to be associated with other factors. Objectives: The present study investigated the relationship between TC and human papillomavirus (HPV) infection. Material and methods: Clinical records and surgically resected specimens from 86 patients (
ISSN:0001-6489
1651-2251
DOI:10.1080/00016489.2018.1541506