Oxygen Electrode With Pyrolyzed CoTMPP Catalyst: Application in Glucose Biosensor

Amperometric oxygen sensors employing non-platinum electrocatalyst made from pyrolyzed cobalt-tetramethoxy-phenylporphyrin (CoTMPP) are described. A technique for the preparation of an oxygen working electrode with catalyst from a pressed matrix (tablet) is presented. This technique allows manufactu...

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Bibliographic Details
Published in:Analytical letters 1997-02, Vol.30 (3), p.503-514
Main Authors: Gamburzev, S., Atanasov, P., Wilkins, E.
Format: Article
Language:English
Subjects:
Biological and medical sciences
Biosensors
Biotechnology
Fundamental and applied biological sciences. Psychology
Glucose biosensor
Methods. Procedures. Technologies
Oxygen electrode
Pyrolyzed cobalt-tetramethoxy-phenylporphyrin catalyst
Various methods and equipments
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Summary:Amperometric oxygen sensors employing non-platinum electrocatalyst made from pyrolyzed cobalt-tetramethoxy-phenylporphyrin (CoTMPP) are described. A technique for the preparation of an oxygen working electrode with catalyst from a pressed matrix (tablet) is presented. This technique allows manufacturing numerous electrodes from the same pressed tablet, all of which demonstrate good reproducibility of their parameters. Glucose biosensors are constructed using this oxygen electrode as a basic transducer for amperometric detection of oxygen consumption. The enzyme (glucose oxidase) is held in a micro-bioreactor (face side closed by a Silastic coated polycarbonate membrane) in which the oxygen sensor is immersed. Linearity of the sensor response to glucose concentrations up to 16 mM is reported. Sensors demonstrated a stable signal (varying within ±5% of its average value) during 15 days of continuous in vitro glucose monitoring at 37°C.
ISSN:0003-2719
1532-236X
DOI:10.1080/00032719708001797