Spectrophotometric Determination of Amlodipine Besylate in Pure Forms and Tablets

Two simple and sensitive spectrophotometric methods for the determination of amlodipine besylate (ADB) in pure forms and tablets are described. These methods are based on the formation of an ion association complex between the drug and an acidic dye, Bromothymol blue, which is extractable into chlor...

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Bibliographic Details
Published in:Analytical letters 1997-01, Vol.30 (1), p.121-133
Main Authors: Sridhar, K., Sastry, C. S.P., Reddy, M. N., Sankar, D. G., Srinivas, K. Rama
Format: Article
Language:English
Subjects:
3-methyl-2-benzothiazolinone hydrazone hydrochloride
amlodipine besylate
Analysis
Biological and medical sciences
bromothymol blue
General pharmacology
ion association complex
Medical sciences
oxidative coupling
Pharmacology. Drug treatments
Visible spectophotometry
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Summary:Two simple and sensitive spectrophotometric methods for the determination of amlodipine besylate (ADB) in pure forms and tablets are described. These methods are based on the formation of an ion association complex between the drug and an acidic dye, Bromothymol blue, which is extractable into chloroform and has an absorption maximum at 405nm (Method-A), or by the formation of an oxidative coupling product with 3-methyl-2-benzothiazolinone hydrazone hydrochloride (MBTH) in the presence of ceric ammonium sulphate (absorption maximum at 630nm (Method-B)). Beer's Law limits for Methods A and B are 5 to 40 μg/ml. All variables in these methods are optimised and the reaction mechanisms are presented. No interferences were observed from tablet additives and the applicability of the methods was examined by analysing tablets containing ADB. The quantities determined were 99.5-100.2% of the expected value.
ISSN:0003-2719
1532-236X
DOI:10.1080/00032719708002295