Quantification of Arsenic Species in Wheat Flour Samples by Ion Chromatography Coupled to High Resolution Inductively Coupled Plasma-Mass Spectrometry (IC-HR-ICP-MS)

A method was developed for arsenic speciation of South African wheat flour by microwave-assisted extraction with ion chromatography (IC) separation and detection with high resolution inductively coupled plasma-mass spectrometry (IC-HR-ICP-MS). Method optimization included development of the extracti...

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Bibliographic Details
Published in:Analytical letters 2022-09, Vol.55 (18), p.2860-2875
Main Authors: Thosago, Magadima Mary, Botha, Angelique, Ambushe, Abayneh Ataro, Godeto, Taddese Wondimu
Format: Article
Language:English
Subjects:
Arsenates
Arsenic
Arsenic speciation
Chromatography
Deionization
Elution
Emission spectroscopy
Evaluation
Flour
Food
High resolution
Inductively coupled plasma mass spectrometry
ion chromatography coupled to high resolution inductively coupled plasma-mass spectrometry (IC-HR-ICP-MS)
Mass spectrometry
Optimization
Quality assessment
Rice
Scientific imaging
Selectivity
Separation
Speciation
Wheat
wheat flour
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Summary:A method was developed for arsenic speciation of South African wheat flour by microwave-assisted extraction with ion chromatography (IC) separation and detection with high resolution inductively coupled plasma-mass spectrometry (IC-HR-ICP-MS). Method optimization included development of the extraction and elution methods for baseline separation of the As-species in the samples. The As-species were successfully extracted using deionized water and baseline separation was attained using a gradient elution method with 0.5 mM HNO 3 (pH 3.4) and 50 mM HNO 3 (pH 1.4). Method validation parameters, including trueness (bias), precision, linearity, limit of detection (LOD), limit of quantification (LOQ) and selectivity were evaluated to assess the quality of the results. Three certified reference materials (CRMs), NIST SRM 1568b (rice flour), NMIJ CRM 7533-a (brown rice flour), and ERM BC211 (brown rice flour) were used to evaluate the trueness of the developed method. Low limits of detection and quantification were achieved (0.3 to 2.6 pg g −1 and 1.1 to 8.6 pg g −1 , respectively) for the As-species. The dominant peaks in the wheat flour were arsenite (As(III)), dimethyl arsenic acid (DMA), and arsenate (As(V)). The concentrations of the inorganic (iAs), i.e., As(III) and As(V) in the wheat flour were very low from 6.8 to 17.8 ng g −1 , with a relative expanded uncertainty ( ) of
ISSN:0003-2719
1532-236X
DOI:10.1080/00032719.2022.2075883