In vitro studies on the evaluation of mycotoxin detoxifying agents for their efficacy on deoxynivalenol and zearalenone

A simple in vitro system was developed to study the efficacy of commercially available mycotoxin detoxifying agents and adsorbing substances as feed additives to detoxify deoxynivalenol (DON) and zearalenone (ZON) in situ. The in vitro model simulates the conditions (pH, temperature and transit time...

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Bibliographic Details
Published in:Archives of animal nutrition 2004-08, Vol.58 (4), p.311-324
Main Authors: Döll, S, Dänicke, S, Valenta, H, Flachowsky, G
Format: Article
Language:English
Subjects:
Adsorbents
Adsorption
Aluminum Silicates - metabolism
Animal Feed - analysis
Animal Feed - microbiology
Animals
Anion Exchange Resins - metabolism
Buffers
Charcoal - metabolism
Cholestyramine Resin - metabolism
Deoxynivalenol
Detoxification
Dose-Response Relationship, Drug
Estrogens, Non-Steroidal - administration & dosage
Estrogens, Non-Steroidal - metabolism
Food Additives - pharmacology
Food Contamination - prevention & control
Hydrogen-Ion Concentration
In vitro
In Vitro Techniques
Models, Biological
Mycotoxins
Mycotoxins - administration & dosage
Mycotoxins - metabolism
Swine
Time Factors
Treatment Outcome
Trichothecenes - administration & dosage
Trichothecenes - metabolism
Zearalenone
Zearalenone - administration & dosage
Zearalenone - metabolism
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Summary:A simple in vitro system was developed to study the efficacy of commercially available mycotoxin detoxifying agents and adsorbing substances as feed additives to detoxify deoxynivalenol (DON) and zearalenone (ZON) in situ. The in vitro model simulates the conditions (pH, temperature and transit time) of the porcine gastrointestinal tract, as pigs react most sensitively to these mycotoxins. The commercially available products were not effective in detoxifying DON and ZON under the applied conditions, while activated carbon was able to bind both toxins and cholestyramine, and a modified aluminosilicate showed good adsorption abilities for ZON. Data obtained in dose dependency studies showed an estimated adsorption capacity of cholestyramine and the modified aluminosilicate of 11.7 and 5.7 g ZON/kg detoxifying agent. The in vitro system deployed in the present study was demonstrated to be a simple, helpful tool in screening substances for their ability to detoxify DON and ZON under the simulated conditions of the porcine gastrointestinal tract. Nonetheless in vivo experiments are indispensable to proof the efficacy.
ISSN:1745-039X
1477-2817
DOI:10.1080/00039420412331273268