Thyroid hormone-responsive protein mediates the response of chicken liver to fasting mainly through the cytokine-cytokine receptor interaction pathway

1. The objective of this study was to explore the mediating role of thyroid hormone-responsive protein (THRSP) in the response of chicken liver to fasting. 2. A batch of 7-d-old chicks with similar body weights were randomly divided into the control group and the fasting group (n = 10). The control...

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Bibliographic Details
Published in:British poultry science 2023-11, Vol.64 (6), p.733-744
Main Authors: Mu, J., Zhou, X., Xing, Y., Zhang, M., Zhang, J., Li, F., Ge, J., Zhao, M., Liu, L., Gong, D., Geng, T.
Format: Article
Language:English
Subjects:
cell growth
cytokine
immune response
nutrition
Poultry
THRSP
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Summary:1. The objective of this study was to explore the mediating role of thyroid hormone-responsive protein (THRSP) in the response of chicken liver to fasting. 2. A batch of 7-d-old chicks with similar body weights were randomly divided into the control group and the fasting group (n = 10). The control group was fed ad libitum, while the test group fasted for 24 h. The liver and pectoral muscle tissues were collected. Chicken primary hepatocytes or myocytes were treated with different concentrations of thyroxine, glucose, insulin, oleic acid and palmitic acid, separately. Chicken primary hepatocytes were transfected with THRSP overexpression vector vs. empty vector, and the cells were used for transcriptome analysis. The mRNA expression of THRSP and other genes was determined by quantitative PCR. 3. The expression of THRSP in chicken liver and pectoral muscle tissues was significantly inhibited by fasting (P 
ISSN:0007-1668
1466-1799
DOI:10.1080/00071668.2023.2246135