EVIDENCE FOR A ROLE OF DOPAMINERGIC MECHANISMS IN THE IMMUNOSTIMULATING EFFECT OF µ-OPIOID RECEPTOR AGONIST DAGO

The present study demonstrates that: (1) activation of µ-opioid receptors by systemic administration of a highly selective agonist DAGO (100 µg/kg) results in a significant increase in the number of plaque- and rosette-forming cells in the spleen of CBA mice as well as Wistar rats on the 5th day fol...

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Bibliographic Details
Published in:International journal of neuroscience 2003-10, Vol.113 (10), p.1381-1394
Main Authors: DEVOINO, LIDIA, CHEIDO, MARGARITA, ALPERINA, ELIZAVETA, IDOVA, GALINA
Format: Article
Language:English
Subjects:
Analgesics, Opioid - pharmacology
Animals
Cerebellar Nuclei - immunology
Cerebellar Nuclei - injuries
Dopamine - metabolism
Dopamine Antagonists - pharmacology
dopaminergic systems
Enkephalin, Ala-MePhe-Gly- - pharmacology
Erythrocytes - immunology
Haloperidol - pharmacology
Hemolytic Plaque Technique
hypophysis
Hypothalamus - immunology
Hypothalamus - injuries
Immunization
Immunoglobulin M - biosynthesis
Male
Mice
Mice, Inbred CBA
Neuroimmunomodulation
neuroimmunostimulation
Nucleus Accumbens - immunology
Nucleus Accumbens - injuries
Pituitary Gland - immunology
Pituitary Gland - injuries
Rats
Rats, Wistar
Receptors, Opioid, mu - agonists
Rosette Formation
Sheep
Species Specificity
Spleen - drug effects
the nuclei caudatus and accumbens
μ-opioid receptors
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Summary:The present study demonstrates that: (1) activation of µ-opioid receptors by systemic administration of a highly selective agonist DAGO (100 µg/kg) results in a significant increase in the number of plaque- and rosette-forming cells in the spleen of CBA mice as well as Wistar rats on the 5th day following sheep red blood cells (5 &#50 108) immunization, (2) the immunostimulatory effect of DAGO is mediated by central mechanisms including the hypothalamus-hypophysis complex; (3) the postsynaptic dopamine (DA) receptors of D2 type are involved in the DAGO-induced immunostimulation since the combined treatment of animals with haloperidol (2 mg/kg), a blocker of DA D2 receptors, and DAGO abolished this effect; (4) the nuclei caudatus and accumbens of the nigrostriatal and mesolimbic DAergic systems, respectively, are implicated in the immune response stimulation caused by DAGO.­­
ISSN:0020-7454
1563-5279
1543-5245
DOI:10.1080/00207450390231437