EFFECTS OF EXTRACT OF GINKGO BILOBA ON INTRACRANIAL PRESSURE, CEREBRAL PERFUSION PRESSURE, AND CEREBRAL BLOOD FLOW IN A RAT MODEL OF SUBARACHNOID HAEMORRHAGE

• Published in: International journal of neuroscience 2007-05, Vol.117 (5), p.655-665
• Main Authors: SUN, BAO-LIANG, YUAN, HUI, YANG, MING-FENG, XIA, ZUO-LI, ZHANG, SU-MING, WANG, LE-XIN
• Format: Article
• Language: English
• Subjects: Analysis of Variance; Animals; Blood Pressure - drug effects; cerebral blood flow; Cerebral Cortex - blood supply; Cerebral Cortex - drug effects; cerebral perfusion pressure; Cerebrovascular Circulation - drug effects; Disease Models, Animal; Female; Ginkgo biloba; Ginkgo biloba - chemistry; intracranial pressure; Intracranial Pressure - drug effects; Laser-Doppler Flowmetry - methods; Male; Perfusion; Plant Extracts - therapeutic use; Rats; Rats, Wistar; Regional Blood Flow - drug effects; subarachnoid haemorrhage; Subarachnoid Hemorrhage - drug therapy; Subarachnoid Hemorrhage - pathology; Subarachnoid Hemorrhage - physiopathology; Time Factors
• ISSN: 0020-7454; 1563-5279; 1543-5245
• DOI: 10.1080/00207450600773871

The purpose of this study was to investigate in effect of extract of Ginkgo biloba (EGb) on cerebral blood perfusion in a subarachnoid haemorrhage (SAH) rat model. SAH lead to an increase in intracranial pressure and decrease in cranial perfusion pressure and regional cerebral blood flow in all groups. However, the intracranial pressure increases in EGb groups were less than that of the vehicle group (p < .01), whereas the reduction in cranial perfusion pressure and regional cerebral blood flow in the EGb group was less than that of the vehicle and SAH groups (p < .01). It was concluded that EGb attenuates the increase in intracranial pressure and reduction in cerebral blood perfusion after SAH.