The Effect of Heme Oxygenase Inhibition on Visual Evoked Potentials

This study investigated the effect of heme oxygenase (HO) inhibition on visual evoked potentials (VEPs). HO catalyzes the oxidative degradation of heme. Products of HO reaction are biliverdin, ferrous iron, and carbon monoxide (CO). CO is a signal molecule and is an endogenous modulator in the solub...

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Bibliographic Details
Published in:International journal of neuroscience 2009, Vol.119 (9), p.1384-1398
Main Authors: Feyza, Savcioglu, Deniz, Akpinar, Piraye, Yargicoglu, Aysel, Agar
Format: Article
Language:English
Subjects:
Animals
Arsenites - pharmacology
Enzyme Activators - pharmacology
Enzyme Induction - drug effects
Enzyme Inhibitors - pharmacology
Evoked Potentials, Visual - drug effects
heme oxgenase inhibition
Heme Oxygenase (Decyclizing) - antagonists & inhibitors
Heme Oxygenase (Decyclizing) - biosynthesis
heme oxygenase-2
Indazoles - pharmacology
Male
Metalloporphyrins - pharmacology
Oxadiazoles - pharmacology
Protoporphyrins - pharmacology
Quinoxalines - pharmacology
Rats
Rats, Sprague-Dawley
Sodium Compounds - pharmacology
tin protoporphyrin IX
Visual Pathways - drug effects
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Summary:This study investigated the effect of heme oxygenase (HO) inhibition on visual evoked potentials (VEPs). HO catalyzes the oxidative degradation of heme. Products of HO reaction are biliverdin, ferrous iron, and carbon monoxide (CO). CO is a signal molecule and is an endogenous modulator in the soluble guanylate cyclase/cyclic guanosine monophosphate signaling pathway. Rats were treated with HO inhibitors tin protoporphyrin IX (SnPP IX) or zinc protoporphyrin IX (ZnPP IX) or HO inducer sodium arsenite (Na-arsenite). Soluble guanylate cyclase is inhibited by 1H-[1,2,3]oxydiazolo[4,3-a]quinoxalin-1-one (ODQ) and induced by 3-(5′-hydroxymethyl-2′-furyl)-1-benzyl indazole (YC-1). VEPs were recorded under mild ether anesthesia with the help of stainless steel subdermal electrodes and a photic stimulator. SnPP IX, ODQ or SnPP IX + YC-1 injections significantly prolonged latencies of P3; however, Na-arsenite shortened latency of P3. It has been shown that HO affects VEPs.
ISSN:0020-7454
1563-5279
1543-5245
DOI:10.1080/00207450902961950