Personality disorders characterized by anxiety predict Alzheimer's disease in women: A case-control studies

This research is geared toward the evaluation of current and pre-morbid personality psychopathology in Alzheimer's disease (AD). The study was conducted with four groups who were administered the Personality Diagnostic Questionnaire-4+, mainly in the form of individual interviews. Current measu...

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Bibliographic Details
Published in:The Journal of general psychology 2020-10, Vol.147 (4), p.414-431
Main Authors: Henriques-Calado, Joana, Duarte-Silva, Maria Eugénia
Format: Article
Language:English
Subjects:
Alzheimer's disease
Anxiety disorders
mental health
Morbidity
Neurodegenerative diseases
Obsessive compulsive disorder
Personality
Personality disorders
Psychopathology
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Summary:This research is geared toward the evaluation of current and pre-morbid personality psychopathology in Alzheimer's disease (AD). The study was conducted with four groups who were administered the Personality Diagnostic Questionnaire-4+, mainly in the form of individual interviews. Current measurement: AD Group, 44 female participants (M = 81.36 years); Control Group, 80 female participants from the population at large (M = 75.84 years). Pre-morbid measurement: AD Group Informants (n = 40); Control Group Informants (n = 42). The incidence of all clusters in clinical state are significant, and Cluster B incidence in pre-morbidity is evidenced. Cluster C is highlighted throughout the life course as a predictor. Logistic regression analyses showed that schizotypical, narcissistic, avoidant, obsessive-compulsive, pre-morbid schizotypical, pre-morbid histrionic, and pre-morbid obsessive-compulsive personality disorders, predicted the presence of AD diagnosis, accounting for 49% of the variance. These findings are relevant to research relating personality and psychopathology in Alzheimer's disease.
ISSN:0022-1309
1940-0888
DOI:10.1080/00221309.2019.1697637