Spinal chloroma presenting with triplegia in an aleukaemic patient

Malignant myeloid blast cells may occasionally form a solid mass in tissues outside the haemopoietic system. These tumours are known as chloromas or granulocytic sarcomas. Chloromas occur most commonly in the context of acute myelogenous leukaemia but, rarely, they occur in the absence of other haem...

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Bibliographic Details
Published in:Pathology 2001, Vol.33 (3), p.386-389
Main Authors: Buckland, Michael E., Scolyer, Richard A., Donellan, Michael B., Brew, Stefan, McGee-Collett, Martin, Harper, Clive G.
Format: Article
Language:English
Subjects:
acute leukaemia
central nervous system
Chloroma
granulocytic sarcoma
myeloid leukaemia
paresis
pathology
spinal cord
spinal cord compression
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Summary:Malignant myeloid blast cells may occasionally form a solid mass in tissues outside the haemopoietic system. These tumours are known as chloromas or granulocytic sarcomas. Chloromas occur most commonly in the context of acute myelogenous leukaemia but, rarely, they occur in the absence of other haematological disease, and may be misdiagnosed as lymphoma. A case of a previously well 35-year-old woman presenting with rapidly progressive triplegia caused by a paraspinal and extradural cervical chloroma with no evidence of bone marrow or other haematological involvement is described. Few cases of spinal cord compression caused by chloroma in otherwise healthy patients have been reported. Morphological features of myeloid differentiation, histochemistry and immunohis-tochemistry, may all aid in rapid diagnosis and allow early and appropriate therapy.
ISSN:0031-3025
1465-3931
DOI:10.1080/00313020126312