Differentiation of obese patients at moderate or higher Findrisc score based on their atherogenic index

Objectives: The purpose of this study was to reveal different subgroups of patients with at least moderate risk of developing diabetes in the next 10 years, based on clustering of cardiovascular risk factors. Methods: We performed a one-center cross-sectional study of adult patients (n = 109, median...

Full description

Saved in:
Bibliographic Details
Published in:Postgraduate medicine 2016-11, Vol.128 (8), p.790-796
Main Authors: Andreeva-Gateva, Pavlina A., Konsulova, Petya, Orbetzova, Maria, Georgieva-Nikolova, Radka, Tafradjiiska-Hadjiolova, Radka, Angelova, Violina, Voynikov, Yulian, Nikolova, Irina, Simova, Iscra
Format: Article
Language:English
Subjects:
Adult
Aged
atherogenic index of plasma
Atherosclerosis - epidemiology
Blood Glucose
Body Weights and Measures
C-Reactive Protein
Cardiovascular Diseases - epidemiology
Cross-Sectional Studies
Diabetes Mellitus, Type 2 - epidemiology
diabetes type 2 risk
Diet
Exercise
Female
Glucose Tolerance Test
Humans
Hypertension - epidemiology
inflammation
Insulin Resistance
Lipids - blood
Male
Middle Aged
Obesity
Obesity - epidemiology
prediabetes
Prospective Studies
Risk Factors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Objectives: The purpose of this study was to reveal different subgroups of patients with at least moderate risk of developing diabetes in the next 10 years, based on clustering of cardiovascular risk factors. Methods: We performed a one-center cross-sectional study of adult patients (n = 109, median age 45 years) with Findrisc score of above 11 out of 26 maximum. We included in the cluster analysis anthropometrics, lipid and carbohydrate parameters obtained in oral glucose tolerance test (OGTT), insulin, C-peptide, creatinine, C-reactive protein, liver enzymes, beta-cell function, insulin sensitivity and insulin resistance (HOMA calculations). We also evaluated the atherogenic index of plasma (AIP). Results: We identified three metabolic phenotypes of patients with at least moderate Findrisc score-one 'male' (cluster AM, n = 24), and two 'female' phenotypes (cluster AW, n = 9 and cluster BW, n = 76). Men were almost homogenous for their metabolic phenotype, with lower fat percentage than women (p 
ISSN:0032-5481
1941-9260
DOI:10.1080/00325481.2016.1240590