Acute and sub-chronic antihypertensive properties of Taraxacum officinale leaf (TOL) and root (TOR)

Taraxacum officinale (T. officinale) is a leafy vegetable that is commonly used traditionally as a diuretic agent. In the current study, we aimed at exploring the potential antihypertensive effect of T. officinale using two animal models of hypertension. Acute and sub-chronic antihypertensive effect...

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Bibliographic Details
Published in:Transactions of the Royal Society of South Africa 2019-05, Vol.74 (2), p.132-138
Main Authors: Aremu, Olukayode O., Tata, Charlotte M., Sewani-Rusike, Constance R., Oyedeji, Adebola O., Oyedeji, Opeoluwa O., Gwebu, Ephraim T., Nkeh-Chungag, Benedicta N.
Format: Article
Language:English
Subjects:
Antihypertensive
Asteracea
L-NAME
Lipids
Oxidative stress
T. officinale
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Summary:Taraxacum officinale (T. officinale) is a leafy vegetable that is commonly used traditionally as a diuretic agent. In the current study, we aimed at exploring the potential antihypertensive effect of T. officinale using two animal models of hypertension. Acute and sub-chronic antihypertensive effects of TOL and TOR at 500 mg/kg/bwt were evaluated in spontaneously hypertensive rats and L-NAME-induced hypertensive rats, respectively. Wistar rats were treated daily with L-NAME (40 mg/kg/bwt) until they became hypertensive and were then allocated to various treatment groups: control, furosemide (10 mg/kg/bwt) TOL (500 mg/kg/bwt) and TOR (500 mg/kg/bwt) for 4 weeks. Blood samples were collected for determination of the lipid profile. Results showed that one-off oral administration of TOL and TOR significantly (p 
ISSN:0035-919X
2154-0098
DOI:10.1080/0035919X.2019.1592031