Reduction of F ENO by tap water and carbonated water mouthwashes: magnitude and time course

Fractional exhaled nitric oxide (F ) assesses eosinophilic inflammation of the airways, but F values are also influenced by oral nitric oxide (NO). The aim of this pilot study was to measure F and compare the effect of two different mouthwashes on F and analyse the duration of the effect. F was meas...

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Bibliographic Details
Published in:Scandinavian journal of clinical and laboratory investigation 2018-02, Vol.78 (1-2), p.153-156
Main Authors: Lassmann-Klee, Paul Guenther, Lindholm, Tuula, Metsälä, Markus, Halonen, Lauri, Sovijärvi, Anssi Raimo Antero, Piirilä, Päivi
Format: Article
Language:English
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Summary:Fractional exhaled nitric oxide (F ) assesses eosinophilic inflammation of the airways, but F values are also influenced by oral nitric oxide (NO). The aim of this pilot study was to measure F and compare the effect of two different mouthwashes on F and analyse the duration of the effect. F was measured in 12 randomized volunteers (healthy or asthmatic subjects) with a NIOX VERO® analyser at an expiratory flow rate of 50 mL/s. After a baseline measurement, a mouthwash was performed either with tap water or carbonated water and was measured during 20 min in 2 min intervals. The procedure was repeated with the other mouthwash. We found that both mouthwashes reduced F immediately at the beginning compared to the baseline (p 
ISSN:0036-5513
1502-7686
DOI:10.1080/00365513.2017.1419574