A prospective study on the correlation between thromboelastometry and standard laboratory tests - influence of type of surgery and perioperative sampling times

This prospective study aimed at investigating the influence of surgery type and perioperative sampling times on the correlations between rotational thromboelastometry (ROTEM) parameters and standard laboratory coagulation tests assessing comparable coagulation phases. Patients undergoing glioblastom...

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Published in:Scandinavian journal of clinical and laboratory investigation 2020-04, Vol.80 (3), p.179-184
Main Authors: Leal-Noval, Santiago R., Fernández-Pacheco, José, Casado-Méndez, Manuel, Cancela, Paloma, Narros, José L., Arellano-Orden, Victoria, Dusseck, Reginald, Díaz-Martín, Ana, Muñoz-Gómez, Manuel
Format: Article
Language:English
Subjects:
Cancer
exTEM
fibrinogen
fibTEM
glioblastoma
prothrombin time
ROTEM
surgery
VHA
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Summary:This prospective study aimed at investigating the influence of surgery type and perioperative sampling times on the correlations between rotational thromboelastometry (ROTEM) parameters and standard laboratory coagulation tests assessing comparable coagulation phases. Patients undergoing glioblastoma multiforme resection (GBR group, n = 60) or laparoscopic colon cancer resection (CCR group, n = 40) were prospectively included. Blood samples for ROTEM and laboratory assessments were consecutively drawn within 24-hours prior to surgery (baseline), and at 2, 24 and 48-hours after surgery. Correlations between perioperative ExTEM clotting-time (CT-exTEM) and prothrombin time (PT), and between FibTEM maximum clot firmness (MCF-fibTEM) with and plasma fibrinogen (pFB) concentration (Clauss method), were evaluated using the Spearman's rho test. The efficiency of recommended cut-offs of CT-exTEM (>75 s) and MCF-fibTEM (15 s) or a low pFB (
ISSN:0036-5513
1502-7686
DOI:10.1080/00365513.2019.1704051