Circadian variations in plasma concentrations of cholecystokinin and gastrin in man

Cholecystokinin (CCK) is a gut hormone which regulates gallbladder contraction and pancreatic enzyme secretion. In addition, CCK is also a major intestinal satiety signal. The knowledge about CCK in circulation, however, has been limited by difficulties in accurate measurement of the concentrations...

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Bibliographic Details
Published in:Scandinavian journal of clinical and laboratory investigation 2020-11, Vol.80 (7), p.546-551
Main Authors: Rehfeld, Jens F., Sennels, Henriette P., Jørgensen, Henrik L., Fahrenkrug, Jan
Format: Article
Language:English
Subjects:
Cholecystokinin (CCK)
circadian variation
diagnosis
gastrin
immunoassay specificity
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Summary:Cholecystokinin (CCK) is a gut hormone which regulates gallbladder contraction and pancreatic enzyme secretion. In addition, CCK is also a major intestinal satiety signal. The knowledge about CCK in circulation, however, has been limited by difficulties in accurate measurement of the concentrations in plasma. Thus, CCK circulates in low concentrations and furthermore, it is structurally homologous to the antral hormone, gastrin, which circulates in higher concentrations. Therefore, most antibodies raised against CCK cross-react in immunoassays with gastrin. However, using highly sensitive and entirely specific in-house radioimmunoassays, which meet these challenges, we have now measured the daily concentration-variations of CCK and gastrin in plasma from young healthy men (n = 24). Plasma was sampled every third hour from each person during 24 h. The results show that the gastrointestinal secretion of both CCK and gastrin in man display significant circadian variations.
ISSN:0036-5513
1502-7686
DOI:10.1080/00365513.2020.1804072