Evaluation of the Diesse Cube 30 touch erythrocyte sedimentation method in comparison with Alifax test 1 and the manual Westergren gold standard method

The erythrocyte sedimentation rate (ESR) is a traditional nonspecific laboratory test used for the assessment of inflammation. Even if its usefulness is nowadays being largely debated, it is still considered a valuable laboratory test in selected clinical conditions, such as rheumatoid diseases, ort...

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Bibliographic Details
Published in:Scandinavian journal of clinical and laboratory investigation 2021-05, Vol.81 (3), p.181-186
Main Authors: Pieri, Massimo, Pignalosa, Stefano, Perrone, Marco Alfonso, Russo, Carmelo, Noce, Gianluca, Perrone, Andrea, Terrinoni, Alessandro, Massoud, Renato, Bernardini, Sergio
Format: Article
Language:English
Subjects:
Blood Sedimentation - instrumentation
Blood Sedimentation - methods
Blood Sedimentation - standards
comparison
Erythrocyte sedimentation rate
ESR
evaluation
Female
Hematocrit
Hemoglobins - analysis
Humans
Male
Regression Analysis
Westergren method
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Summary:The erythrocyte sedimentation rate (ESR) is a traditional nonspecific laboratory test used for the assessment of inflammation. Even if its usefulness is nowadays being largely debated, it is still considered a valuable laboratory test in selected clinical conditions, such as rheumatoid diseases, orthopedic infections and Hodgkin's lymphoma, and it can be used for the infectious, inflammatory, malignancies, and autoimmune diseases follow-up. The introduction of new methodologies on semi-automated and automated analyzers started about four decades ago and opened a new era of ESR analysis characterized by shorter assay time, use of (EDTA) undiluted blood, that increases sample stability and allows using a single sample for also other hematologic tests, and greater safety for laboratory personnel. In this context, the aim of this study was to evaluate the performances of new device Diesse Cube 30 touch, comparing it with Alifax Test 1 and with the gold standard Westergren method. The new Diesse Cube 30 touch for determination of the ESR shows a good correlation with the manual Westergren gold standard method in a shorter time, and in a standardized way, since all the phases of the test are automatized. The Diesse Cube 30 touch respect the manual gold standard method, displayed a small bias to confirm that the new automated test system tended to have a small bias for ESR values (mean positive bias +0.2 mm/h). The findings of the present study show that the Diesse Cube 30 touch Westergren-based method can be a valid alternative in laboratory analysis for the determination of ESR.
ISSN:0036-5513
1502-7686
DOI:10.1080/00365513.2021.1881996