Evaluation of a novel probe based on laser Doppler flowmetry and comparison with photo plethysmography for assessment of the skin perfusion pressure

This study aims to compare skin perfusion pressure measurements (SPP) at midfoot and below knee level performed with a novel laser Doppler flowmetry (LD) probe with a reference method based on photo plethysmography (PP). It includes 40 patients referred with known or suspected peripheral arterial di...

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Published in:Scandinavian journal of clinical and laboratory investigation 2022-05, Vol.82 (3), p.238-245
Main Authors: Thøgersen, Karin Folmer, Rasmussen, Karl Keigo, Høyer, Christian, Zerahn, Bo
Format: Article
Language:English
Subjects:
Blood circulation
Humans
Laser-Doppler flowmetry
Laser-Doppler Flowmetry - methods
observer variation
Perfusion
Peripheral Arterial Disease - diagnosis
photopletysmography
Plethysmography
Reproducibility of Results
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Rasmussen, Karl Keigo
Høyer, Christian
Zerahn, Bo
description This study aims to compare skin perfusion pressure measurements (SPP) at midfoot and below knee level performed with a novel laser Doppler flowmetry (LD) probe with a reference method based on photo plethysmography (PP). It includes 40 patients referred with known or suspected peripheral arterial disease. The SPP was performed with both devices. Blinded re-interpretation of the SPP measurements was carried out by three observers and a consensus quality score was provided for each measurement. SPP >40 mmHg was considered a clinically relevant cut-off. This study evaluates a total of 48 paired measurements of the midfoot and 54 below knee. The two methods agreed in overall diagnostic classification in 80 of 102 measurements (78%) with both methods showing SPP ≥40 mmHg in 21 cases, and both methods showing SPP
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Analysis of inter observer variation for the LD readings showed an intraclass correlation coefficient of 0.880 (95% CI: 0.807 to 0.929, p- value &lt;0.05) at midfoot, and 0.933 (95% CI: 0.894 to 0.959, p-value &lt;0.05) at below knee level. 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source Taylor and Francis:Jisc Collections:Taylor and Francis Read and Publish Agreement 2024-2025:Medical Collection (Reading list)
subjects Blood circulation
Humans
Laser-Doppler flowmetry
Laser-Doppler Flowmetry - methods
observer variation
Perfusion
Peripheral Arterial Disease - diagnosis
photopletysmography
Plethysmography
Reproducibility of Results
title Evaluation of a novel probe based on laser Doppler flowmetry and comparison with photo plethysmography for assessment of the skin perfusion pressure
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