Autoimmune Enteropathy in an Adult with Autoimmune Multisystemic Involvement

We describe the case of a 58-year-old woman with autoimmune enteropathy associated with thyroiditis, gastritis, transitory neutropenia, sicca syndrome and severe axonal polyneuropathy of autoimmune origin. Enterocyte autoantibodies were not detected. However, predisposition to autoimmune disease was...

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Bibliographic Details
Published in:Scandinavian journal of gastroenterology 2002-09, Vol.37 (9), p.1012-1016
Main Authors: Casis, B., Fernández-Vázquez, I., Barnardos, E., Saiz, A., Ballestín, C., Morillas, J. D., Colina, F., Solís-Herruzo, J. A.
Format: Article
Language:English
Subjects:
Autoantibodies - analysis
Autoimmune Diseases - complications
Autoimmune Diseases - drug therapy
Autoimmune Diseases - pathology
Autoimmune Enteropathy
Autoimmunity
Biological and medical sciences
CD4-Positive T-Lymphocytes - immunology
CD8-Positive T-Lymphocytes - immunology
Diarrhea - complications
Digestive system
Female
Gastritis - complications
Gastritis - drug therapy
Gastritis - pathology
Glucocorticoids - therapeutic use
Humans
Intractable Diarrhoea
Investigative techniques, diagnostic techniques (general aspects)
Malabsorption Syndromes - complications
Medical sciences
Middle Aged
Neutropenia - complications
Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques
Polyneuropathies - complications
Polyneuropathies - drug therapy
Polyneuropathies - pathology
Prednisolone - therapeutic use
Sjogren's Syndrome - complications
Sjogren's Syndrome - drug therapy
Sjogren's Syndrome - pathology
Thyroiditis, Autoimmune - complications
Thyroiditis, Autoimmune - drug therapy
Thyroiditis, Autoimmune - pathology
Treatment Outcome
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Description
Summary:We describe the case of a 58-year-old woman with autoimmune enteropathy associated with thyroiditis, gastritis, transitory neutropenia, sicca syndrome and severe axonal polyneuropathy of autoimmune origin. Enterocyte autoantibodies were not detected. However, predisposition to autoimmune disease was indicated by the presence of high titres of anti-gastric parietal cell, anti-thyroglobulin, anti-thyroid peroxidase and anti-neutrophil antibodies. CD4+ and CD8+ lymphocytes were equally distributed in the lamina propria of the small intestine, but CD8+ cells were highly represented among intraepithelial lymphocytes.
ISSN:0036-5521
1502-7708
DOI:10.1080/003655202320378185