Gastric mucosa-associated lymphoid tissue lymphoma and Helicobacter pylori: Scratch and win

Gastric mucosa-associated lymphoid tissue (MALT) lymphoma is generally associated with Helicobacter pylori infection and, in the great majority of patients, regresses after eradication. H. pylori-negative MALT lymphoma occurs in a small minority of cases in which treatment is based on surgery or che...

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Bibliographic Details
Published in:Scandinavian journal of gastroenterology 2005-01, Vol.40 (1), p.115-119
Main Authors: Franco, Monica, Rugge, Massimo, D'Andrea, Emma, Mescoli, Claudia, Menin, Chiara, Farinati, Fabio
Format: Article
Language:English
Subjects:
Adult
Antibodies, Monoclonal - therapeutic use
Antibodies, Monoclonal, Murine-Derived
Bacterial diseases
Bacterial diseases of the digestive system and abdomen
Biological and medical sciences
Biopsy, Needle
CD20 monoclonal antibody
Female
Follow-Up Studies
Gastric Mucosa - microbiology
Gastric Mucosa - pathology
Gastroscopy
Helicobacter Infections - complications
Helicobacter Infections - diagnosis
Helicobacter pylori
Helicobacter pylori - isolation & purification
Hematologic and hematopoietic diseases
Human bacterial diseases
Humans
Immunohistochemistry
Infectious diseases
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Lymphoma, B-Cell, Marginal Zone - complications
Lymphoma, B-Cell, Marginal Zone - diagnosis
Lymphoma, B-Cell, Marginal Zone - drug therapy
MALT lymphoma
Medical sciences
Risk Assessment
Rituximab
Stomach Neoplasms - complications
Stomach Neoplasms - diagnosis
Treatment Outcome
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Description
Summary:Gastric mucosa-associated lymphoid tissue (MALT) lymphoma is generally associated with Helicobacter pylori infection and, in the great majority of patients, regresses after eradication. H. pylori-negative MALT lymphoma occurs in a small minority of cases in which treatment is based on surgery or chemoradiotherapy. In the search for H. pylori based on histology and the C13 urea breath test, this report describes a case with a series of false-negative results, thus confirming the possibility of a lower detectability of H. pylori in patients with MALT gastric lymphoma and supporting the use of additional tests in evaluating such pathology, including polymerase chain reaction. Additionally, treatment with CD20 monoclonal antibody (rituximab) is suggested as an alternative to surgery or treatment with chemotherapy or radiotherapy in patients with truly H. pylori-negative gastric MALT lymphoma.
ISSN:0036-5521
1502-7708
DOI:10.1080/00365520410009438