Staphylococcus aureus skin/soft-tissue infections: The impact of SCCmec type and Panton-Valentine leukocidin

We assessed the role of Panton-Valentine leukocidin (PVL) and SCCmec type in community associated (CA) and healthcare associated (HC) Staphylococcus aureus (SA) skin/soft-tissue infections (STI). We prospectively monitored microbiology results (11 January 2005 to 6 January 2006), screened inpatients...

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Bibliographic Details
Published in:Scandinavian journal of infectious diseases 2008, Vol.40 (8), p.601-606
Main Authors: Jahamy, Houssein, Ganga, Roopa, Al Raiy, Basel, Shemes, Stephen, Nagappan, Vijayalakshmi, Sharma, Mamta, Riederer, Kathleen, Khatib, Riad
Format: Article
Language:English
Subjects:
Adult
Aged
Analysis of Variance
Bacterial diseases
Bacterial Toxins - genetics
Bacterial Toxins - metabolism
Biological and medical sciences
Community-Acquired Infections - microbiology
Cross Infection - microbiology
Exotoxins - genetics
Exotoxins - metabolism
Female
Genes, Bacterial
Human bacterial diseases
Humans
Infectious diseases
Latex Fixation Tests
Leukocidins - genetics
Leukocidins - metabolism
Male
Medical sciences
Methicillin-Resistant Staphylococcus aureus - classification
Methicillin-Resistant Staphylococcus aureus - genetics
Methicillin-Resistant Staphylococcus aureus - pathogenicity
Middle Aged
Polymerase Chain Reaction
Regression Analysis
Soft Tissue Infections - microbiology
Soft Tissue Infections - pathology
Staphylococcal Infections - microbiology
Staphylococcal Infections - pathology
Staphylococcal infections, streptococcal infections, pneumococcal infections
Staphylococcal Skin Infections - microbiology
Staphylococcal Skin Infections - pathology
Staphylococcus aureus
Staphylococcus aureus - classification
Staphylococcus aureus - genetics
Staphylococcus aureus - pathogenicity
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Summary:We assessed the role of Panton-Valentine leukocidin (PVL) and SCCmec type in community associated (CA) and healthcare associated (HC) Staphylococcus aureus (SA) skin/soft-tissue infections (STI). We prospectively monitored microbiology results (11 January 2005 to 6 January 2006), screened inpatients with SA in tissue samples or blood, and selected adults with STI. We recorded clinical/microbiological characteristics, and tested saved isolates for PVL genes (real time PCR) and SCCmec type (conventional multiplex PCR). We encountered 204 patients. MRSA strains that accounted for 70.5% CA and 66.0% HC cases, caused more abscesses (55.7% vs 29.7%; p=0.001) and were often PVL-positive (68.9% vs 4.8%; p
ISSN:0036-5548
1651-1980
DOI:10.1080/00365540701877312