Quantitavive Proton Magnetic Resonance Analysis of Ranitidine in Solid Dosage Forms

A rapid and specific proton magnetic resonance (PMR) spectroscopic method was developed for determining ranitidine hydrochloride in tablets. 2-Choloroacetophenon was used as the internal standard and DMSO-d 6 served as the PMR solvent. The concentration of drug per unit dose was calculated from the...

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Bibliographic Details
Published in:Spectroscopy letters 1997-07, Vol.30 (5), p.835-841
Main Authors: Özden, Tuncel, Üngörmüş, Ahmet, Tosun, Ali, Ersan, Seyhan
Format: Article
Language:English
Subjects:
PMR Analysis
Ranitidine
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Summary:A rapid and specific proton magnetic resonance (PMR) spectroscopic method was developed for determining ranitidine hydrochloride in tablets. 2-Choloroacetophenon was used as the internal standard and DMSO-d 6 served as the PMR solvent. The concentration of drug per unit dose was calculated from the integration values for the resonance signals of ranitidine hydrochloride at 4.32 δ ppm and int. st. at 5.19 δ ppm. The method using commercial products gave comparable results to those obtained by the methods of UV spectroscopy and USP XXIII.
ISSN:0038-7010
1532-2289
DOI:10.1080/00387019708001632