Preparation and Purification of Desethylamiodarone Hydrochloride

Reaction of the free base of amiodarone with 1-chloroethyl chloroformate in toluene gives desethylamiodarone, which can be easily purified and converted to the hydrochloride salt.

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Bibliographic Details
Published in:Synthetic communications 2006-11, Vol.36 (22), p.3371-3376
Main Authors: Lucas, Anthony N., Tanol, Mehmet, McIntosh, Michelle P., Rajewski, Roger A.
Format: Article
Language:English
Subjects:
Amiodarone
chloroethyl chloroformate
dealkylation
desethylamiodarone
metabolite
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Description
Summary:Reaction of the free base of amiodarone with 1-chloroethyl chloroformate in toluene gives desethylamiodarone, which can be easily purified and converted to the hydrochloride salt.
ISSN:0039-7911
1532-2432
DOI:10.1080/00397910600941406