Synthesis of Amphiphilic Amino Alcohols

An efficient and general approach for the synthesis of amphiphilic 1,2-amino alcohols is reported. The use of N-benzyl protecting groups is essential for obtaining good yields when opening a long-chain terminal epoxide with an amine.

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Bibliographic Details
Published in:Synthetic communications 2008-11, Vol.38 (23), p.4295-4313
Main Authors: Toom, Lauri, Villo, Piret, Liblikas, Ilme, Vares, Lauri
Format: Article
Language:English
Subjects:
Amino alcohols
amphiphiles
epoxide opening
N-benzyl protecting group
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Description
Summary:An efficient and general approach for the synthesis of amphiphilic 1,2-amino alcohols is reported. The use of N-benzyl protecting groups is essential for obtaining good yields when opening a long-chain terminal epoxide with an amine.
ISSN:0039-7911
1532-2432
DOI:10.1080/00397910802326554