Novel and Efficient Synthesis of Pyrimidine Derivatives

A new series of 1-alkyl-2-oxo-1,2-dihydro-pyrimidine-5-carboxalic acid amides is described. The reaction of N-((E)-3-(dimethylamino)-2-formylacryloyl) formamidine, an intermediate obtained by Vilsmeier-Haack formylation of acetonitrile with various mono-substituted ureas, provides such compounds in...

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Bibliographic Details
Published in:Synthetic communications 2010-01, Vol.40 (11), p.1580-1587
Main Authors: Ghagare, Maruti G., Birari, Dilip R., Shelar, Deepak P., Toche, Raghunath B., Jachak, Madhukar N.
Format: Article
Language:English
Subjects:
Derivatives
Monosubstituted ureas
nucleophilic vinylic substitution
pyrimidine derivatives
synthesis
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Summary:A new series of 1-alkyl-2-oxo-1,2-dihydro-pyrimidine-5-carboxalic acid amides is described. The reaction of N-((E)-3-(dimethylamino)-2-formylacryloyl) formamidine, an intermediate obtained by Vilsmeier-Haack formylation of acetonitrile with various mono-substituted ureas, provides such compounds in good yields.
ISSN:0039-7911
1532-2432
DOI:10.1080/00397910903108521