Total Synthesis of (±)-Glabridin

An efficient formal synthesis of (±)-glabridin was accomplished in 10 steps from resorcinol using Raney Ni to reduce carbon-carbon double bonds in α , β -unsaturated carbonyl compound as the key step. [Supplementary materials are available for this article. Go to the publisher's online edition...

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Bibliographic Details
Published in:Synthetic communications 2014-02, Vol.44 (4), p.540-546
Main Authors: Ji, Wen-Hua, Gao, Qian-Shan, Lin, Yun-Liang, Gao, Hong-Mei, Wang, Xiao, Geng, Yan-Ling
Format: Article
Language:English
Subjects:
Chemoselective reduction
glabridin
resorcinol
total synthesis
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Summary:An efficient formal synthesis of (±)-glabridin was accomplished in 10 steps from resorcinol using Raney Ni to reduce carbon-carbon double bonds in α , β -unsaturated carbonyl compound as the key step. [Supplementary materials are available for this article. Go to the publisher's online edition of Synthetic Communications® for the following free supplemental resource(s): Full experimental and spectral details.]
ISSN:0039-7911
1532-2432
DOI:10.1080/00397911.2013.821616