Efficient ecofriendly synthesis of pyrazole acryloyl analogs by amino acid catalysis

An easy and effective green approach of Knoevenagel condensation and arylidene formation with the substrates involves pyrazole-3-carbaldehydes and active methylenes under catalytic action of glycine (the simplest amino acid) in dimethylsulfoxide. These reactions were successfully carried out at room...

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Bibliographic Details
Published in:Synthetic communications 2016-04, Vol.46 (8), p.701-709
Main Authors: Chaudhry, Faryal, Asif, Nadia, Shafqat, Syed Salman, Khan, Amir Azam, Munawar, Munawar Ali, Khan, Misbahul Ain
Format: Article
Language:English
Subjects:
Active methylenes
Amino acids
arylidenes
Catalysis
glycine
Knoevenagel condensation
pyrazole-3-carbaldehyde
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Summary:An easy and effective green approach of Knoevenagel condensation and arylidene formation with the substrates involves pyrazole-3-carbaldehydes and active methylenes under catalytic action of glycine (the simplest amino acid) in dimethylsulfoxide. These reactions were successfully carried out at room temperature.
ISSN:0039-7911
1532-2432
DOI:10.1080/00397911.2016.1164863