Facile and efficient synthesis of chiral sulfoxide esters: Versatile tool in asymmetric synthesis

Facile and efficient synthesis of sulfoxide esters using menthols as chiral auxiliary is described. Phenylthio/benzylthio/naphthylthioacetic esters act as an efficient substrate for chiral sulfoxides via oxidation in one step. The structural and stereochemical aspects of target product were establis...

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Bibliographic Details
Published in:Synthetic communications 2019-01, Vol.49 (2), p.279-285
Main Authors: Nagpal, Reshma, Bhalla, Aman, Bhalla, Jitender, Bari, Shamsher S., Thapar, Renu
Format: Article
Language:English
Subjects:
Chemical analysis
chiral sulfoxide ester
Esters
Fourier transforms
menthol
NMR
Nuclear magnetic resonance
Oxidation
Substrates
Sulfoxides
Synthesis
β-Lactams
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Summary:Facile and efficient synthesis of sulfoxide esters using menthols as chiral auxiliary is described. Phenylthio/benzylthio/naphthylthioacetic esters act as an efficient substrate for chiral sulfoxides via oxidation in one step. The structural and stereochemical aspects of target product were established on the basis of various spectroscopic studies, namely FT-IR, NMR ( 1 H NMR and 13 C NMR) and elemental analysis. This method is simple, fast, convenient and very efficient.
ISSN:0039-7911
1532-2432
DOI:10.1080/00397911.2018.1554145