Efficient and stereoselective synthesis of thiosulfinates from disulfide using cumene hydroperoxide in the presence of titanium-based catalyst systems

An efficient and stereoselective procedure of oxidizing disulfide to thiosulfinate 2a using CHP as the oxidant and economically available Ti(O-i-Pr) 4 /L-DET/H 2 O as catalysts were developed. The reaction went smoothly under mild conditions with synthetic useful yield and the workup for obtaining t...

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Bibliographic Details
Published in:Synthetic communications 2019-05, Vol.49 (9), p.1165-1172
Main Authors: Sun, Pengju, Huang, Jiansheng, Xu, Jinyi, Yu, Niefang
Format: Article
Language:English
Subjects:
Catalysis
Catalysts
Chemical industry
Cumene
Cumene hydroperoxide
FK228
HDAC
Oxidation
stereoselective
Stereoselectivity
thiosulfinates
Titanium
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Summary:An efficient and stereoselective procedure of oxidizing disulfide to thiosulfinate 2a using CHP as the oxidant and economically available Ti(O-i-Pr) 4 /L-DET/H 2 O as catalysts were developed. The reaction went smoothly under mild conditions with synthetic useful yield and the workup for obtaining the final product is quite convenient.
ISSN:0039-7911
1532-2432
DOI:10.1080/00397911.2019.1590847