PEG-assisted one-pot three-component synthesis of 1,3-oxazino quinoline and chromeno 1,3-oxazin derivatives under catalyst free condition

A straightforward and greener PEG-assisted protocol has been disclosed for the cascade synthesis of [1,3]Oxazino quinoline, and chromeno[1,3]oxazin derivatives via three component reaction of multifarious aromatic amines with formaldehyde and 4-hydroxyquinoline-2(1H)-one or 4-methylumbelliferone by...

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Bibliographic Details
Published in:Synthetic communications 2020-05, Vol.50 (10), p.1456-1467
Main Authors: Yadav, Maruti B., Balwe, Sandip Gangadhar, Kim, Jong Tae, Cho, Byung Gwon, Jeong, Yeon Tae
Format: Article
Language:English
Subjects:
[1,3]oxazino quinoline
Amines
Chromeno 1,3-oxazin
Derivatives
Hydroxyquinoline
multicomponent reactions (MCRs)
polyethylene glycol (PEG-600)
Quinoline
Substrates
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Summary:A straightforward and greener PEG-assisted protocol has been disclosed for the cascade synthesis of [1,3]Oxazino quinoline, and chromeno[1,3]oxazin derivatives via three component reaction of multifarious aromatic amines with formaldehyde and 4-hydroxyquinoline-2(1H)-one or 4-methylumbelliferone by using very convenient reaction conditions. This methodology represents a sustainable approach for rapid access to a library of diversity oriented highly pure [1,3]oxazino scaffolds with broad substrate scope.
ISSN:0039-7911
1532-2432
DOI:10.1080/00397911.2020.1737129