Synthesis of 1,3-diaryl butanones from acetophenones via a tandem reaction

A tandem reaction for the simple construction of 1,3-diaryl butanones from acetophenones was developed. Anhydrous HI was generated in situ by the promotion of the [Rh]- complex with molecular hydrogen and iodine. The acetophenones undergo aldol reactions by anhydrous HI firstly, and then hydrogenati...

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Bibliographic Details
Published in:Synthetic communications 2020-06, Vol.50 (12), p.1790-1798
Main Authors: Li, Sida, Laishram, Ronibala Devi, Shen, Guoli, Zhang, Xuexin, Yang, Yong, Ni, Jianxiao, Zhan, Yong, Zhou, Yongyun, Fan, Baomin
Format: Article
Language:English
Subjects:
Acetophenones
Aldehydes
aldol reaction
anhydrous HI
Cascade chemical reactions
Hydrogen storage
Iodine
molecular hydrogen
molecular iodine
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Summary:A tandem reaction for the simple construction of 1,3-diaryl butanones from acetophenones was developed. Anhydrous HI was generated in situ by the promotion of the [Rh]- complex with molecular hydrogen and iodine. The acetophenones undergo aldol reactions by anhydrous HI firstly, and then hydrogenation reactions by the same [Rh]-complex to generate the corresponding 1,3-diaryl butanones in one pot.
ISSN:0039-7911
1532-2432
DOI:10.1080/00397911.2020.1755871