Asymmetric α-hydroxylation of β-dicarbonyl compounds by C-2′ modified cinchonine-derived phase-transfer catalysts in batch and flow microreactors

The asymmetric α-hydroxylation of β-dicarbonyl compounds was catalyzed by C-2′-modified cinchonine-derived phase-transfer catalysts. Excellent yields (up to 95%) and good enantioselectivities (up to 89% ee) were obtained. The reaction was carried out in a flow microreactor and similar results were o...

Full description

Saved in:
Bibliographic Details
Published in:Synthetic communications 2020-08, Vol.50 (16), p.2478-2487
Main Authors: Tang, Xiao-Fei, Zhao, Jing-Nan, Wu, Yu-Feng, Zheng, Ze-Hao, Ma, Cun-Fei, Yu, Zong-Yi, Yun, Lei, Liu, Guang-Zhi, Meng, Qing-Wei
Format: Article
Language:English
Subjects:
Asymmetric
Asymmetry
Carbonyl compounds
Hydroxylation
microreactor
Microreactors
oxidation
Phase transfer catalysts
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The asymmetric α-hydroxylation of β-dicarbonyl compounds was catalyzed by C-2′-modified cinchonine-derived phase-transfer catalysts. Excellent yields (up to 95%) and good enantioselectivities (up to 89% ee) were obtained. The reaction was carried out in a flow microreactor and similar results were obtained (up to 93% yield, 84% ee), the residence time was shortened from 24 h in batch to 2 h.
ISSN:0039-7911
1532-2432
DOI:10.1080/00397911.2020.1781183