Triethylamine-catalyzed unprecedented synthesis of 2-amino-4-phenylbenzo [4, 5] imidazo [1,2-a] pyrimidine-3-carbonitrile under solvent free condition

An efficient and experimentally straightforward method for the synthesis of 2-amino-4-phenylbenzo [4,5] imidazo [1,2-a] pyrimidine-3-carbonitrile derivatives has been developed via one pot three-component reaction of 2-aminobenzimidazole, cyanoacetamide and aromatic aldehydes in the presence of trie...

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Bibliographic Details
Published in:Synthetic communications 2021-06, Vol.51 (12), p.1913-1922
Main Authors: Yadav, Maruti B., Lim, Kwon Taek, Kim, Jong Su, Jeong, Yeon Tae
Format: Article
Language:English
Subjects:
Aldehydes
Aminobenzimidazole
Chemical synthesis
Column chromatography
Functional groups
Green chemistry
multicomponent reactions (MCRs)
one-pot reaction
Reaction time
solvent-free reaction
Solvents
Triethylamine
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Summary:An efficient and experimentally straightforward method for the synthesis of 2-amino-4-phenylbenzo [4,5] imidazo [1,2-a] pyrimidine-3-carbonitrile derivatives has been developed via one pot three-component reaction of 2-aminobenzimidazole, cyanoacetamide and aromatic aldehydes in the presence of triethylamine under solvent-free reaction condition. This green procedure offers several advantages such as high atom economy, short reaction time, metal-free and solvent-free reaction conditions, easy work up and column chromatography-free method with a wide range of functional group tolerance. This has made the protocol sustainable and economical.
ISSN:0039-7911
1532-2432
DOI:10.1080/00397911.2021.1913605